Zhewitra 10 mg contains vardenafil as the active ingredient, which is a phosphodiesterase type 5 (PDE5) inhibitor. The primary mechanism of action of Zhewitra 10 mg is to treat erectile dysfunction (ED) in men.
Inhibition of PDE5: When a man is sexually stimulated, the body releases nitric oxide in the erectile tissue of the penis. Nitric oxide activates an enzyme called guanylate cyclase, which leads to an increase in the levels of cyclic guanosine monophosphate (cGMP).
Relaxation of Blood Vessels: cGMP plays a crucial role in relaxing the smooth muscles of the blood vessels in the penis, allowing them to dilate and increase blood flow to the erectile tissues. This increased blood flow is essential for achieving and maintaining an erection.
Blockage of PDE5: PDE5 is an enzyme that breaks down cGMP, leading to a decrease in its levels and the constriction of blood vessels. Vardenafil in Zhewitra 10 mg inhibits the action of PDE5, preventing it from breaking down cGMP. As a result, cGMP levels remain elevated, and the blood vessels continue to relax, promoting sustained blood flow to the penis, which helps to achieve and maintain an erection.
It's important to note that sexual stimulation is still required to trigger the release of nitric oxide and initiate the chain of events that lead to an erection. Vardenafil in Zhewitra 10 mg does not cause automatic erections; it enhances the body's natural response to sexual stimulation.